The other important fi ndings are the nature of obesity as a risk factor abdominal obesity is. Updated with slides results of the interheart study have shown that nine modifiable risk factors predict more than 90% of acute mi cases. Reproduced with permission from yusuf s, hawken s, ounpuu s, et al, for the interheart study investigators. The interheart study done in 52 countries, emphasizes the role of behavioral and conventional risk factor. The most important risk factor by far was cholesteroltwice as important as exercisefollowed by smoking. China study unprocessed fruits properly cooked vegetables some vegetable oils, fish few refined carbohydrates avoid meats. Jan 25, 2017 yusuf ps, hawken s, ounpuu s, dans t, avezum a, lanas f, mcqueen m, budaj a, pais p, varigos j, lisbeug l. Introduction premature myocardial infarction mi generally refers to mi in men. Tobacco use and risk of myocardial infarction in 52 countries. Investigators note that the impact of the risk factors. Information extracted from the medical files was used to describe the gps. Char ept 16 acute coronary syndromes oxford medicine.
Twenty year trends and sex differences in young adults. This cohort study investigates the incidence, risk factors, and outcomes associated with inhospital acute myocardial infarction ami among a population of patients hospitalized in us veterans health administration facilities. Incidence, risk factors, and outcomes associated with in. Full text full text is available as a scanned copy of the original print version. The relative importance of coronary artery disease cad risk varies globally. Tobacco use and risk of myocardial infarction in 52. Disclosures none we are all on death row, the only. Even in the interheart study, odds of any form stress whether at work or. Interheart a global study of risk factors for acute myocardial infarction in 52 countries. Question what are the incidence, risk factors, and outcomes associated with inhospital acute myocardial infarction ami findings this cohort study of 1. Background lowcarbohydrate diets are associated with cardiovascular risk factors. European guidelines on cardiovascular disease prevention in clinical practice.
Cholesterol lowering in intermediaterisk persons without. Premature mi is a major contributor to cardiovascular disease cvd, which claimed 17. Karthikeyan g, teo kk, islam s, mcqueen mj, pais p, wang x, sato h, lang cc, sitthiamorn c, pandey mr, kazmi k, sanderson je, yusuf s. Retrospective us cohort study data from a retrospective cohort study of 8,231 patients with type 2 diabetes and 8,845 nondiabetic patients of similar age and sex, based in the united states of america. However, we cannot agree with their statement that the effect of stress on acute myocardial infarction was consistent across different geographic regions. To assess characteristics of coronary arterial lesion cal by means of invasive coronary angiography in young patients, aged lancet 2004. The odds ratios differ from 111 99% ci 0897 for central and eastern europe to 2. Tobacco use and risk of myocardial infarction in 52 countries in the interheart study. Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 648 controls from 52 countries the interheart study. Risk factors for early myocardial infarction in south asians. The burden and management of ischemic heart disease. The functional variant rs1048990 in psma6 is associated with. Fourth joint task force of the european society of cardiology and other societies on cardiovascular. Effectiveness of a pharmacistled cardiovascular risk.
A case report is a description of a single case that reveals a novel. Risk factors for firsttime acute myocardial infarction. Risk factors associated with premature myocardial infarction. The interheart study showed the feasibility, value, and importance of a large standardised international casecontrol study 29 972 participants to establish the importance of, and relation between, key risk factors for myocardial infarction in 52 countries of high, middle, and low income, with participation from every inhabited. Therefore, we investigated the relationship between depression, anxiety, education, social isolation and.
Although there is strong evidence to support the role of psychosocial factors in cardiovascular mortality, there is a scarcity of knowledge about how these factors are related. Request pdf effect of potentially modifiable risk factors associated with. Marc newell, md minneapolis heart institute foundation abbott. Risk factors for ischaemic and intracerebral haemorrhagic.
The further import of interheart is that its data allow. Prevention of coronary heart disease with pravastatin in men with. Changing lifestyle could prevent 90% of heart disease. What about the interheart study on heart attack risk factors. Psychosocial factors have shown independent predictive value in the development of cardiovascular diseases. Yusuf ps, hawken s, ounpuu s, dans t, avezum a, lanas f, mcqueen m, budaj a, pais p, varigos j, lisbeug l. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries the interheart study. Athens kidney center 1440 north chase street athens, ga. Prevalence and cardiovascular disease correlates of low. The effects of lowcarbohydrate diets on cardiovascular. Yusuf s, hawken s, ounpuu s, dans t, avezum a, lanas f, mcqueen m, budaj a, pais p, varigos j, lisheng l, interheart study investigators. Purpose the aim of this metaanalysis was to assess the relationship between lowcarbohydrate diets and cardiovascular risk factors.
The impact of preoperative anxiety and education level on. Sleep duration, snoring habits and risk of acute myocardial. Yusuf s, hawken s, ounpuu s, dans t, avezum a, lanas f, et al. However, a majority of this data is collected from white adult males and is extrapolated to. Results for interheart study 1 40 of 60 sorted by relevance date click export csv or ris to download the entire page or use the checkboxes to select a subset of records to download export csv export ris 10 per page 50 per page 100 per page 250 per page. The interheart study is uniquely positioned to address the.
The sample comprised 251 ami patients hospitalized between march 1, 2011 and april 30, 2012 and 464 age and sex. Reducing premature mi and cvd is a key priority for all nations. The interheart study was funded by the canadian institutes of health research. Get a printable copy pdf file of the complete article 350k. Population attributable risk par is estimating the proportion of a disease that can theoretically be attributed to a specific risk factor.
In the interheart study, waisttohip ratio was a better predictor of coronary disease than was bmi. Jan 19, 2018 the relative importance of coronary artery disease cad risk varies globally. Cardiovascular complications of hiv aahivm provider. What about the interheart study on heart attack risk. Sponsored by the world health organization, the interheart study you point out was indeed a monumental undertaking, trying to tease out modifiable risk factors for heart attacks across populations in more than 50 countries on every inhabited continent. The results of the interheart study1 show that the factors associated with coronary heart disease are essentially the same wherever in the world people experience an acute myocardial infarction. Effect of potentially modifiable risk factors associated. Cad is the most expensive condition treated in hospitals. Marc newell, md minneapolis heart institute foundation. The aim of this study was to determine cad risk factors for acute myocardial infarction ami among patients in public health care institutions in trinidad using a casecontrol type study design. Interheart a global study of risk factors for acute. Get a printable copy pdf file of the complete article 350k, or click on a page image below to browse page by page. Sep 14, 2012 psychosocial factors have shown independent predictive value in the development of cardiovascular diseases.
There was a statistically significant reduction in systolic blood pressure of 4. The contribution of lifestyle to allcause mortality in cad. Clearly, the study indicates that to avoid a stroke, it is most important to control arterial hypertension, stop smoking, and lose weight especially around the abdomen. Independent risk factors for mi interheart study lancet 2004. Intensity and timing of statin initiation in patients with. The designated discussant at the european society of cardiology congress, where the results were first reported, lamented mankind is doing a. Advantages disadvantages quick and cheap when investigating rare conditions recall bias difficult to prove causation 4. The interheart study an international casecontrol analysis of the risk factors for a first myocardial infarction conducted in more than 15,000 patients presenting with myocardial infarction in 52 countries showed that the median age at presentation with myocardial infarction was 51 years in the middle east. Defi ning and setting national goals for cardiovascular health promotion and disease reduction.
Mrcbhf heart protection study of cholesterol lowering with simvastatin in 20,536 highrisk individuals. The patients paper files were used to collect baseline data and most recent measurements, which were recorded on a data collection sheet. Method four electronic databases pubmed, embase, medline, and the cochrane library were searched from their inception. We congratulate annika rosengren and colleagues sept 11, p 9531 on their well done study. Effect of potentially modifiable risk factors associated with. The interheart study, a global casecontrol study of first acute mi carried out in 52 countries, has reported that nine potentially modifiable risk factors smoking, diabetes, abdominal obesity, etc contribute to mi in both sexes and in all regions of the world. Coronary artery disease cad is major risk factor of myocardial ischemia, the leading cause of death in developed western countries including the united states. Full text is available as a scanned copy of the original print version. Article in the lancet 3649438 january 2004 with 221 reads. Yusuf and others published effect of potentially modifiable risk factors. A global study of risk factors for acute myocardial infarction.
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